Tuesday, January 31, 2012

Mexico detects stolen fuel at gas station

(AP) ? Mexican officials said Monday they have found a new distribution point for thousands of gallons of gasoline stolen from state-owned pipelines: a seemingly normal gas station with official logos.

Thieves in Mexico had long been thought to unload stolen oil products on shadowy black markets. But it now appears the thefts have taken on a new sophistication, using a gas station that until 2010 had a concession from the state-owned Petroleos Mexicanos company, known as Pemex, to legally sell gas.

A Pemex official who was not authorized to be quoted by name said Monday that it was the first time that stolen fuel has been detected being sold through a gas station. In the past, primitive illicit fueling stations with improvised tanks had been discovered in fields, vacant lots and industrial buildings, presumably to supply fuel to private fleets.

But in a raid over the weekend in the northern city of Monterrey, the federal Attorney General's Office said it found about 12,690 gallons (48,000 liters) of stolen gasoline at the station, worth about $77,000. The station came under suspicion because it had not had a legitimate delivery of gas in some time.

Photos of the station showed that it had the normal green, red and white signs borne by all Pemex gas stations throughout Mexico. Pemex licenses the stations to be run by private concessionaires, who must buy fuel from the company. The Attorney General's Office said the Monterrey station's concession had been canceled in 2010.

The company is taking the threat seriously enough that it is starting a nationwide, random audit of stations throughout the country, in part because the volume of oil products being stolen appears to be too large to move through primitive, improvised outlets.

The company says it lost about 2.99 million barrels, or about 125 million gallons, of oil products in the first 11 months of 2011, the latest figures available. That represented about a full day's worth of total production for the company, and marked a 52-percent increase over the 1.96 million barrels stolen in the same period of 2010.

According to a U.S. court case, Mexican gangs trafficked some stolen crude over the border to U.S. refineries, and in June 2011, Pemex filed a lawsuit against nine U.S. companies and two individuals for alleged involvement in buying or processing Mexican oil products stolen by gangs.

Thieves have also sold unrefined fuels to bulk users such as brick kilns and factories, but the amount of gasoline being stolen would be inappropriate for such uses, or even private truck fleets.

Pemex said the task force will use mobile labs to test stations' gasoline to detect whether it was illicitly mixed or transported. It will also review tax and commercial records to detect whether any station is selling more gas than it has ordered.

But the 1,324 illegal taps and break-ins at Pemex pipelines discovered in 2011 are only part of the complex series of attacks on the company.

A Mexican legislator said Monday that an oil spill in early January in the Gulf coast state of Veracruz was intentionally caused to create a pollution emergency, in order to generate income and contracts for clean-up work.

Federal Congressman Antonio Benitez Lucho toured the Pemex plant where the spill originated and said a primitive cut had been made in a valve head, a hole knocked in a containment wall and a thick hose laid to the edge of the Coatzacoalcos river, which empties into the Gulf of Mexico.

In early January, about 63,400 gallons (240,000 liters) of crude spilled from the valve plant, blackening the river's shores and threatening wildlife.

"There was no doubt that it was deliberate," Benitez Lucho said.

"I think they spilled the crude so that the companies that do clean-up and remediation work ... could get quick, fast-track contracts," he said. "They are million-dollar companies that charge huge amounts for clean-up and remediation, and I think that is the motive."

The office of the Federal Attorney General for Environmental Protection said the case was still under investigation.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-30-LT-Mexico-Oil-Theft/id-fb497627d90747c48c31a8b1ea183dc1

manny pacquiao vs marquez manny pacquiao vs marquez dish network cbs news manny pacquiao fight pacquiao marquez pacquiao marquez

Water leaks found at stricken Japan nuclear plant

Japan's stricken nuclear power plant has leaked more than 160 gallons of water, forcing it to briefly suspend cooling operations at a spent-fuel pond at the weekend, the plant's operator and domestic media said.

  1. Only on msnbc.com

    1. Updated 36 minutes ago 1/30/2012 12:42:25 PM +00:00 Romney: Gingrich attacks ?painful to watch?
    2. Updated 91 minutes ago 1/30/2012 11:47:51 AM +00:00 These Super Bowl ads didn't need toilet humor
    3. Fast food goes around-the-clock
    4. After teen hockey injuries, safety push gains support
    5. NBC News poll: Romney leads Gingrich in Fla.
    6. US coupon craze turns to medical care
    7. Meet 'Rosie' and 'Ken': 2 chimps, many experiments

The Fukushima plant, on the coast north of Tokyo, was wrecked by a huge earthquake and tsunami in March last year, triggering the evacuation of around 80,000 people in the world's worst nuclear crisis in 25 years.

The operator of the complex, the Tokyo Electric Power Co (Tepco), reported two main leakages on its website on Sunday, one from a pump near the plant's office building and another from a back-up cooling system at reactor No.4.

"The cooling water is from a filtrate tank for fire extinction and doesn't contain radioactive materials," Tepco said of the incident at reactor No. 4. It added that some water from the other leakage had flowed into a drain and "we are examining whether this water has flowed into the ocean or not."

The Nikkei newspaper Monday quoted Tepco as saying around 40 liters (10.6 gallons) had leaked from the pool-cooling system of the No. 4 reactor Sunday morning, with probably 600 liters (158.5 gallons) of purified water leaking from another point. Water had also leaked at other facilities within the complex, the Nikkei added.

However, the Nikkei newspaper quoted Tepco Monday as saying that it believed no water had escaped into the sea.

"The leakage is believed to have been caused by freezing due to cold weather, and the leaked water included radioactively contaminated water that has been purified," the Nikkei said in its online edition, quoting Tepco. "The contamination level is low."

Meanwhile, Japan's deputy prime minister has acknowledged that the government failed to take minutes of 10 meetings last year on the response to the country's disasters and nuclear crisis and called for officials to compile reports on the meetings retroactively.

Slideshow: A month of misery (on this page)

The missing minutes have become a hot political debate, with opposition lawmakers saying they are necessary to provide a transparent record of the government's discussion after the March 11 earthquake and tsunami touched off the worst nuclear accident since Chernobyl in 1986.

Deputy Prime Minister Katsuya Okada confirmed Friday that the minutes were not fully recorded at the time and called for them to be written up, retroactively, by the end of February. Three of the meetings during the chaotic period had no record at all, not even an agenda, including a government nuclear crisis meeting headed by the prime minister.

Okada has set up a panel to investigate the extent of the problem and its cause.

The missing minutes are the latest example of the government missteps in disclosing information.

Japanese authorities and regulators already have been repeatedly criticized for how they handled information amid the unfolding nuclear crisis. Officials initially denied that the reactors had melted down, and have been accused of playing down the health risks of exposure to radiation.

The government also kept secret a worst-case scenario that tens of millions of people, including Tokyo residents, might need to leave their homes, according to a report obtained recently by The Associated Press.

Reuters and The Associated Press contributed to this report.

Source: http://www.msnbc.msn.com/id/46186286/ns/world_news-asia_pacific/

threadworm nick swisher pirates of silicon valley htc flyer tablet htc flyer tablet hank williams bruins

Monday, January 30, 2012

Feds: Megaupload user data could be gone Thursday

Federal prosecutors say data from users of Megaupload could be deleted as soon as Thursday.

U.S. prosecutors blocked access to Megaupload and charged seven men, saying the site facilitated millions of illegal downloads of movies, music and other content.

The company says its millions of users stored their own data, including family photos and personal documents. They haven't been able to see their data since the government raids earlier this month, but there has been hope would be able to get it back.

Megaupload hires outside companies to store the data, for a fee. But Megaupload attorney Ira Rothken said Sunday that the government has frozen its money.

A letter filed in the case Friday by the U.S. Attorney's Office for the Eastern District of Virginia said storage companies Carpathia Hosting Inc. and Cogent Communications Group Inc. may begin deleting data Thursday. Spokespersons for the two companies and for the U.S. Attorney's Office did not respond to messages Sunday night.

The letter said the government copied some data from the servers but did not physically take them. It said that now that it has executed its search warrants, it has no right to access the data. The servers are controlled by Carpathia and Cogent and issues about the future of the data must be resolved with them, prosecutors said.

Rothken said the company is working with prosecutors to try to keep the data from being erased. He said at least 50 million Megaupload users have data in danger of being erased.

Rothken said that, besides its customers, the data is important to Megaupload so it can defend itself in the legal case.

"We're cautiously optimistic at this point that because the United States, as well as Megaupload, should have a common desire to protect consumers, that this type of agreement will get done," he said.

Megaupload is based in Hong Kong. U.S. authorities said they had authority to act because some of its leased servers are in Virginia.

___

AP Business Writer Daniel Wagner contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-29-Megaupload/id-fcd85f271db7403f9d19a06afc5dac3b

george lucas numerology the game new hampshire primary hue jackson alabama football coachella 2012 line up

Sunday, January 29, 2012

SAG Awards menu is months in the making

In this Oct. 19, 2011 photo, a proposed plate of slow-roasted salmon, roasted root vegetables, and lamb is seen during the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

In this Oct. 19, 2011 photo, a proposed plate of slow-roasted salmon, roasted root vegetables, and lamb is seen during the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

In this Oct. 19, 2011 photo, SAG Awards producer Kathy Connell, left, and SAG Awards supervising producer Mick McCullough participate in the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

In this Oct. 19, 2011 photo, a plate of chopped chicken salad with apples, radicchio, walnuts and whole grain mustard sits on display during the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

In this Oct. 19, 2011 photo, from left, SAG Awards Committee Chair JoBeth Williams, SAG Awards Committee member Paul Napier, chef Suzanne Goin, of Lucques Catering, and SAG Awards event designer Keith Greco take part during the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

In this Oct. 19, 2011 photo, a plate with grilled chicken breast with black rice, pea shoots and tangerine vinaigrette displays during the SAG Awards tasting and table decor preview at Lucques restaurant in Los Angeles. The SAG Awards will be held Sunday, Jan. 29, 2012. (AP Photo/Matt Sayles)

(AP) ? When your dinner party guests include Brad Pitt, George Clooney, Kate Winslet and Glenn Close, and the whole affair is televised live, it can take months to plan the menu. That's why the team behind the Screen Actors Guild Awards began putting together the plate for Sunday's ceremony months ago.

It was still summer when show producer Kathy Connell and executive producer and director Jeff Margolis first sat down with chef Suzanne Goins of Los Angeles eatery Lucques with a tall order: Create a meal that is delicious at room temperature, looks beautiful on TV, is easy to eat and appeals to Hollywood tastes. Oh, and no poppy seeds, soups, spicy dishes, or piles of onions or garlic.

"It can't drip, stick in their teeth or be too heavy," Connell said. "We have to appease all palates."

The chef put together a plate of possibilities: slow-roasted salmon with yellow beets, lamb with couscous and spiced cauliflower and roasted root vegetables with quinoa. There was also a chopped chicken salad and another chicken dish with black beans.

To ensure the dishes are both tasty and TV-ready, Connell and Margolis, along with the SAG Awards Committee and the show's florist and art director, dined together at this summertime lunch on tables set to replicate those that will be in the Shrine Exposition Center during the ceremony. The pewter, crushed-silk tablecloths and white lilies you'll see on TV Sunday were also chosen months ago.

The diners discussed the look of the plate, the size of the portions and the vegetarian possibilities.

"We'd like the portions a little larger," Connell told the chef.

"And a little more sauce on the salmon," Margolis added.

Come Sunday, it's up to Goins to prepare 1,200 of the long-planned meals for the A-list audience.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-01-28-SAG%20Awards-Menu/id-9866ada3ce0a4de98a47b3aa98d94b8c

taylor martinez o brother where art thou o brother where art thou oregon state football oregon state football knocked up knocked up

Fireworks send Beijing air pollution soaring (AP)

BEIJING ? Clouds of smoke from Lunar New Year fireworks sent air pollution in Beijing soaring under a new more sensitive measurement system, reports said Sunday.

Readings of fine particulate matter called PM2.5 reached 1.593 milligrams per cubic meter on the Jan. 22 eve of the holiday, about 100 times worse than the amount considered good for 24-hour exposure, the city's environmental bureau said.

The reading drew wide publicity in the local media on Sunday. The popular Beijing Youth Daily praised the city government for taking a more critical look at air pollution, while urging residents to consider the environmental effects of setting off fireworks.

By noon on Sunday, as people headed back to work after the weeklong holiday, the level stood at a relatively good 0.039.

Concern has grown over air pollution from automobiles and other sources, prompting the city this month to begin announcing measurements of PM2.5 ? particles less than 2.5 micrometers in size. That's about 1/30th the width of an average human hair.

Because of their small size, the particles can lodge deeply in the lungs and are believed to pose the greatest risk to health.

Beijing is frequently cloaked in yellow haze, with buildings a couple of blocks away barely visible.

On particularly bad days, schools cancel outdoor activities due to the risk of respiratory problems and hospitals report increased numbers of people ? particularly the elderly ? seeking help because they're having trouble breathing. Long-term exposure can cause a range of illnesses, especially to the cardiovascular system.

The city previously only released readings of the coarser PM10 standard that often indicated pollution was "light," leading to accusations it was hiding the true extent of the problem.

The U.S. Embassy began independently monitoring PM2.5 from a device on its rooftop and releasing the results via Twitter. Some residents even tested the air in their neighborhoods and posted the results online.

Beijing is now releasing hourly readings of PM2.5 that are taken from a monitoring site about 4 miles (7 kilometers) west of central Tiananmen Square.

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/ap/20120129/ap_on_re_as/as_china_air_quality

blagojevich sentence mythbusters cannonball uss arizona myth busters tracy mcgrady tracy mcgrady mash

Saturday, January 28, 2012

Altria 4Q profit falls 9 pct, CEO to retire (AP)

RICHMOND, Va. ? Marlboro maker Altria Group Inc. said Friday that its fourth-quarter profit fell about 9 percent on lease, legal and restructuring charges even as higher prices and gains from its smokeless tobacco products helped bolster its sales.

The owner of the nation's biggest cigarette maker, Philip Morris USA, also announced that CEO Michael E. Szymanczyk will retire in May following the company's annual shareholder meeting. Altria's board has selected Martin J. Barrington to replace him as CEO and chairman, and David R. Beran will serve as president and chief operating officer.

The company also disclosed that it has entered into an agreement with an affiliate of Fertin Pharma A/S to develop non-combustible nicotine-containing products. Several other tobacco companies have announced similar initiatives to seek cigarette alternatives as demand declines.

"Altria continues to focus on lower-risk products that appeal to adult tobacco consumers," Szymanczyk said in a conference call with investors.

Richmond, Va.-based Altria reported net income of $836 million, or 41 cents per share, for the three-month period ended Dec. 31, down from $919 million, or 44 cents a share, last year. On an adjusted basis, the company earned 50 cents per share, a penny above Wall Street expectations.

Revenue, excluding excise taxes, increased 5 percent to $4.34 billion. Analysts polled by FactSet were expecting $4.23 billion.

Its shares fell 33 cents to $28.34 in morning trading Friday. Its shares have recovered from a 52-week low of $23.20 in early August and are 7 percent below their high for the past year of $30.40 set in mid-December.

Cigarettes volumes were flat at 33.7 billion cigarettes compared with a year ago as an increase of nearly 20 percent in its discount cigarette brands offset declines in its premium brands like Marlboro. Cigarette revenue excluding excise taxes rose 4 percent to $3.63 billion during the quarter on higher prices.

Altria said its top-selling Marlboro brand lost 0.7 points of market share to end up with 41.6 percent of the U.S. market. Marlboro volumes declined less than 1 percent. Its other brands, including Virginia Slims, Parliament and Basic, also lost market share.

The company has introduced several new products with the Marlboro brand, often with lower promotional pricing. They include special blends of both menthol and non-menthol cigarettes to try to keep the brand growing and steal smokers from its competitors.

Altria still faces pressure in the current economy from less-expensive brands such as like Pall Mall from Reynolds American Inc. and Maverick from Lorillard Inc. Marlboro sold for an average of $5.73 per pack during the fourth quarter, compared with an average of $4.24 per pack for the cheapest brand.

Despite changes in market share driven by short-term increases in promotional activity, "Marlboro's underlying brand equity remains strong," Szymanczyk said.

Like other tobacco companies, Altria is focusing on cigarette alternatives ? such as cigars, snuff and chewing tobacco ? for future sales growth because the decline in cigarette smoking is expected to continue.

Volumes of its smokeless tobacco brands such as Copenhagen and Skoal increased about 10 percent. Excluding excise taxes, revenue from its smokeless tobacco business grew nearly 7 percent to $391 million on higher prices.

For the quarter, the company's smokeless tobacco brands had 55.5 percent of the market, which is tiny compared with cigarettes.

Volume for its Black & Mild cigars fell about 6 percent during the period. But revenue excluding excise taxes rose 26 percent to $90 million as it raised prices and spent less money promoting the brand.

Altria also owns a wine business and holds a voting stake in brewer SABMiller.

Altria has been forced to cut costs as tax hikes, smoking bans, health concerns and social stigma make the cigarette business tougher. During the third quarter, the company said it completed a multi-year cost savings program, exceeding its goal of reducing costs by $1.5 billion between 2007 and 2011 compared with 2006.

Last quarter the company rolled out a plan to cut $400 million in "cigarette-related infrastructure costs" by the end of 2013 in advance of anticipated cigarette volume declines. Altria said the restructuring charges in connection with the program totaled 7 cents per share in the fourth quarter.

For the full year, the company said it earned $3.39 billion, or $1.64 per share, in 2011 compared with $3.9 billion, or $1.87 per share, in the previous year. It said its adjusted earnings for the year were $2.05 per share.

Cigarette volumes for the year fell about 4 percent to 135.1 billion cigarettes, largely on declines from Altria's premium brands. Marlboro ended the year with a 42 percent share of the U.S. retail market, down 0.6 points from a year ago. Overall the company lost 0.8 points of market share to end up with 49 percent of the retail market.

Full-year smokeless tobacco volumes increased more than 1 percent to 734.6 million cans or packs, and cigar volumes were stable at 1.25 billion units.

Altria also said it forecast 2012 full-year adjusted earnings between $2.17 and $2.23 per share.

___

Michael Felberbaum can be reached at http://www.twitter.com/MLFelberbaum.

Source: http://us.rd.yahoo.com/dailynews/rss/earnings/*http%3A//news.yahoo.com/s/ap/20120127/ap_on_bi_ge/us_earns_altria_group

benjamin netanyahu prospect park no child left behind no child left behind byu skylab skylab

Jan Brewer vs. Obama: Can you respect the presidency but insult the president?

Arizona Gov. Jan Brewer wagged her finger at President Obama. NHL player Tim Thomas boycotted a White House ceremony. Is the country 'losing basic courtesy and grace'?

It was the finger wag seen ?round the world. Or at least arcing across the blogosphere.

Skip to next paragraph

Arizona Gov. Jan Brewer seeming to lecture President Obama on the tarmac. Mr. Obama pivoting away from Ms. Brewer, apparently before she?d had her full say on immigration.

?It looks like she?s giving him the business,? said Doug Luzader?of Fox News.

Immediately the question became: Was Brewer showing disrespect for the presidency, or merely engaging in brief spirited debate with a fellow politician over one of the hottest issues in an election year?

IN PICTURES: Race in America

?With all due respect? has been a clich? forever, usually uttered just before the rhetorical knife gets inserted.

Like the other night when Herman Cain (remember him?) was giving the ?tea party response? to Obama?s State of the Union speech.

?With all due respect, Mr. President, some of us aren?t stupid,? Mr. Cain said, finishing the sentence with a phrase that could be considered insulting.

?Politics ain?t beanbag,? humorist Finley Peter Dunne?s fictional Mr. Dooley said back during the early 20th?century, and from ridicule to assassination, presidents always have been the brunt of attack.

Abe Lincoln was portrayed in cartoons of the day as ape-like ? long before Barack Obama got the same treatment at some early tea party rallies. George W. Bush?s image frequently mirrored the all-ears ?What, me worry?? kid on the cover of Mad magazine.

But Obama ? the nation?s first African American president ? seems to have endured more of that.

Three years after his election, he?s still battered by ?birthers? challenging the legitimacy of his presidency ? most recently in Georgia, where Republican state lawmakers this week are trying to have him removed from the state?s March 6 primary election ballot based on the charge that he is not a natural born US citizen.

There may have been raucous responses to presidential addresses to Congress in the past, but it was Obama who had to hear Rep. Joe Wilson (R) of South Carolina shout ?You lie!? in 2009 as the president spoke about health care. (Wilson later apologized, sort of.)

This week, Boston Bruins goalie Tim Thomas refused to attend a White House event honoring the Stanley Cup champions, a nonpolitical event if ever there was one. Tea partyer Thomas cited a government that is ?threatening the rights, liberties, and property of the people.?

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/bpTXz52ZR_M/Jan-Brewer-vs.-Obama-Can-you-respect-the-presidency-but-insult-the-president

williston nd williston nd mists of pandaria mists of pandaria 20 20 gunner kiel gunner kiel

Friday, January 27, 2012

Bucs hire Rutgers' Greg Schiano as new coach (AP)

TAMPA, Fla. ? The Buccaneers are counting on Greg Schiano to lead them back to respectability and transform Tampa Bay into consistent winners ? much in the same way he made Rutgers matter again.

The 45-year-old former Scarlet Knights coach was hired Thursday, more than three weeks after the Bucs fired Raheem Morris following a 4-12 finish.

The team scheduled a press conference for Friday to introduce Schiano, who inherits a team that allowed the most points in the NFL this season.

"Coach Schiano is a bright, meticulous teacher who knows how to get the most out of his players," general manager Mark Dominik said. "He built and ran a pro-style program at Rutgers, and he's a defensive-minded coach whose teams have always been characterized by toughness and a physical style of play."

Schiano was at Rutgers for 11 seasons, taking them from college football laughingstocks to a program that has had winning records in six of the last seven years. He was an assistant coach in the NFL with Chicago from 1996-98.

The Scarlet Knights appointed offensive line coach Kyle Flood as interim head coach while the school searches for Schiano's replacement.

The Bucs fired Morris on Jan. 2 after Tampa Bay lost 10 straight games to end the season, most of them by double-digit margins. The collapse following a promising 4-2 start came only a year after the NFL's youngest team went 10-6 and narrowly missed the playoffs.

The Glazer family that owns the team interviewed at least 10 candidates for the opening, including Oregon's Chip Kelly, who was offered the position before turning it down earlier this week.

The Bucs also talked to former NFL head coaches Mike Sherman, Brad Childress and Marty Schottenheimer; Carolina Panthers offensive coordinator Rob Chudzinski; Tennessee Titans defensive coordinator Jerry Gray; Cincinnati Bengals defensive coordinator Mike Zimmer; Green Bay quarterbacks coach Tom Clements and former Packers offensive coordinator Joe Philbin, who accepted the head coaching opening with the Miami Dolphins.

An 11th known candidate, ex-Dallas Cowboys coach and current Houston defensive coordinator Wade Phillips, canceled a scheduled interview with the Bucs that would have taken place while the Texans were in the playoffs.

Bucs co-chairman Joel Glazer said the club was thrilled to entrust the team's rebuilding project to Schiano.

"During our thorough search, we met with numerous impressive candidates, but coach Schiano surely distinguished himself," Glazer said. "From his leadership skills to his considerable track record, he is, simply put, the right man for the job."

It's not the first exhaustive search the Glazers have conducted for a coach.

The Bucs pursued Steve Spurrier before hiring Tony Dungy in 1996, then tried to lure Bill Parcells and Steve Mariucci to Tampa Bay before trading two first-round draft picks, as well as a pair of second-rounders and $8 million cash to the Oakland Raiders in exchange for the opportunity to negotiate a contract with Jon Gruden after the 2001 season.

Gruden led the Bucs to their only Super Bowl title the following season, but Tampa Bay hasn't won a playoff game since. The Glazers fired him three weeks after the Bucs lost the final four games of 2008 to miss the playoffs, and promoted Morris as his successor.

Tampa Bay went 17-31 under Morris, who served as his own defensive coordinator. The Bucs allowed a franchise-record 494 points in 2011, including 31 of more in seven of the last eight games.

In addition to fixing a defense that's been rebuilt over the past two drafts, getting young quarterback Josh Freeman back on track with be a priority this offseason.

Freeman threw for 25 touchdowns and just six interceptions in 2010, his second year in the league and his first as a full-time starter. The 24-year-old passed for 16 TDs vs. 22 interceptions this season.

The timing of the move could put Rutgers in a bind with national signing day less than a week away. This is a pivotal time in the recruiting process, with coaches locking up commitments from high school prospects who make those agreements official by signing national letters of intent starting Wednesday.

Schiano's contract with Rutgers runs through 2016 and pays him around $2.35 million per year.

He played linebacker at Bucknell, but never in the NFL. His first big break in coaching came at Penn State, where Joe Paterno hired him to coach defensive backs in 1991. He was at Penn State through 1995, before being hired by the Bears.

Because of his success at Rutgers, there had often been speculation for years about Schiano possibly replacing Paterno when the Hall of Famer was done coaching. But when Penn State was looking for a replacement after firing Paterno amid a child sex-abuse scandal involving one of his former longtime assistants, the school hired Patriots offensive coordinator Bill O'Brien.

Schiano has been courted by several other colleges during his time at Rutgers, most notably Miami and Michigan.

Michigan pursued Schiano after Lloyd Carr retired in 2007. Schiano passed and the Wolverines hired Rich Rodriguez.

Schiano's first four seasons at Rutgers produced losing seasons, but the program he took over was practically at rock bottom in major college football. Before he was hired, the Scarlet Knights played in only one bowl game in their history.

Schiano brought structure and discipline to a program that sorely lacked both on every level. Not only has Rutgers become a consistent winner in the Big East, but the Scarlet Knights have regularly been among the top teams in the country when it comes to graduating players. He also helped secure funding for multimillion dollar upgrades to Rutgers' facilities, including a major stadium renovation.

In 2005, Rutgers went 7-5 and the next season the Scarlet Knights were 11-2. They played in six bowls under Schiano, winning five, including a victory over Iowa state in the Pinstripe Bowl to cap a 9-4 season in 2011.

___

AP College Football Writer Ralph Russo in New York contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_sp_fo_ne/fbn_buccaneers_schiano

crock pot recipes bob ward bob ward susan lucci jim caviezel arturo gatti arturo gatti

Steam is coming to iOS and Android

Valve Corporation

By Matthew Hawkins

Game developer and publisher Valve has just announced that a version of their Steam client, which?digitally distributes their titles and for many others on the PC and Mac, is coming to smartphones, specifically for iOS and Android users.

The creation of the app was the result of countless requests from the Steam userbase, according to Gabe Newell, co-founder and president of Valve, who explains:

"Seeing which of your friends are online and playing a game, sending quick messages, looking at screenshots for an upcoming game, or catching a sale - these are all features customers have requested. Mobile is changing [the] way people interact, play games and consume media, and the Steam app is part of our commitment to meet customer demands and expand the service functionality of Steam to make it richer and more accessible for everyone."

The client is meant to supplement the existing Steam ecosystem on PC and Mac, and not replace the one found on iOS and Android ? something that both Apple and Google have in place for their devices already. But you can purchase games for your desktop computers though your phone, plus chat with other users and keep tabs on their business.

In that sense, it's similar to the Xbox Live app that iOS users have been using already.?On that note, not only is an Android version forth coming, but Forbes?speculates that Microsoft may also provide Xbox Live games for both platforms. This follows the steps of the Windows Phone version that already allows a degree of interaction between smartphone and console players.

Such functionality from the Steam app is possible, but you can assume that's for later down the road. Meanwhile, it is available for download, but currently in closed beta. To join, simply download the app and try to sign in with your Steam account info; you'll be given notice that your interest has been accounted for, and you'll be added to the list of hopeful beta testers.

Related stories:

?

Matthew Hawkins is a NYC based game journalist who has also written for EGM, GameSetWatch, Gamasutra, Giant Robot, and numerous others. He also self-publishes his own game culture zine, is part of Attract Mode, and co-hosts of The Fangamer Podcast. You can keep tabs on him via?Twitter,?or his personal home-base,?FORT90.com.

Source: http://ingame.msnbc.msn.com/_news/2012/01/26/10244794-steam-is-coming-to-ios-and-android

cj wilson coriolanus coriolanus jon corzine v tech the three stooges top model all stars

GOP Jacksonville Debate Thread (Balloon Juice)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/192025722?client_source=feed&format=rss

knocked up edgar cayce eagle rock music festival eagle rock music festival arbor apple crisp recipe apple crisp recipe

Wednesday, January 25, 2012

Stocks bounce on low interest rate promises

The Dow rose 83 points to close at 12758, its highest close since May 2011, after the Federal Reserve pledged to keep interest rates near zero for almost three more years.

The stock market bounced to its highest close since last spring Wednesday after the Federal Reserve pledged to keep interest rates near zero for almost three more years.

Skip to next paragraph

Bond yields dropped sharply, then climbed back later in the day when investors began looking more closely into the Fed's deliberations. The yield on the five-year Treasury note touched an all-time low.

The big moves in both markets came at 12:30 p.m. (1730 GMT), when the Fed's monetary policy committee said it was unlikely to raise interest rates before late 2014. It had previously promised to keep rates low into the middle of 2013.

The Fed cut rates to near zero in December 2008, during the financial crisis, and has held them there ever since. The announcement was a sign that the Fed expects the economy, which is improving, to need significant help for three more years.

The Dow Jones industrial average was down as much as 95 points in the morning and about 60 points before the Fed announcement. It shot to a gain of 103 points during the afternoon.

The Dow closed up 83.10 points, or 0.7 percent, at 12,758.85. That's the highest close since May. The Dow peaked for last year in April at 12,810. Before that, it had not been so high since May 2008.

In the bond market, the yield on the 10-year Treasury note was at 2.05 percent an hour before the announcement and quickly fell to 1.92, a significant move. It rose to 1.99 percent two hours later.

The bounce-back happened at about 2 p.m. (1900 GMT), when the Fed released details of how the committee voted. Six of its 17 members had favored an interest rate increase this year or next ? well before late 2014 in either case.

The yield on the five-year Treasury note hit 0.76 percent, an all-time low. Bond yields fall when their prices rise.

The Fed's extension of low rates signaled that it expects inflation to stay low. Low inflation makes Treasurys more attractive by helping to maintain the value of bond owners' fixed returns. Rising prices would eat into those returns.

The announcement guaranteed that short-term loans will remain cheap, making it easier for investors to finance longer-term purchases, such as 10- and 30-year Treasurys, said John Canally, investment strategist and economist for LPL Financial.

Monetary decisions by the Fed can change the market's momentum in the short term but rarely have a longer-term impact, Canally warned.

The market changed directions after 22 of the past 24 Fed policy announcements, he said, yet the change evaporates quickly. The market essentially has an equal chance of rising or falling in the five days after Fed meetings, he said.

"It's a coin flip, really," Canally said.

Keeping rates ultra-low for a longer period increases the likelihood that the Fed will engage in more bond-buying programs to help the economy, a policy known as quantitative easing, said Anthony Chan, chief economist with JPMorgan Private Wealth Management. Those tend to boost bond prices by increasing the overall demand in the market.

Chan called the Fed's move insurance against the European debt crisis and a recession across the Atlantic Ocean. Stock buyers, he said, were happy about the prospect of low inflation and a Fed leaning toward promoting economic growth.

The promise of lower rates pushed the dollar lower against other major currencies. Low interest rates make the dollar less attractive because they reduce the returns traders get on U.S. debt and other bonds priced in dollars.

Markets had opened mostly lower on fears about Greece's slow progress in talks with bondholders aimed at reducing that nation's crushing debt load.

Technology stocks rose all morning, bucking the wider market, after Apple reported its best quarter and blew away analyst estimates because of strong holiday sales of the iPhone and iPad.

Apple once again passed Exxon Mobil as the company with the biggest market value. Wall Street was watching the results closely because they were for the company's first quarter since the death of founder Steve Jobs.

Apple stock jumped 6.3 percent, helping lift the Nasdaq composite index by 31.67 points, or 1.1 percent, to close at 2,818.31. The Nasdaq is up 8.2 percent this year, nearly twice the gain for the Dow Jones industrial average.

Netflix Inc., the DVD-by-mail and video streaming provider, jumped 13 percent in after-hours trading after reporting earnings that far exceeded Wall Street's expectations.

The Standard & Poor's 500 index rose 11.41 points, or 0.9 percent, to 1,326.06. The S&P is up 5.4 percent for the year and more than 14 percent from its Nov. 25 low.

As fears recede about Europe, big-time investors such as hedge funds will be drawn back into the market, fueling more gains, said Joe Bell, senior Equity Strategist at Schaeffer's Investment Research.

After such a strong rally, there might be a slight decline, but "overall we're bullish," Bell said.

Among the other companies making big moves after announcing earnings:

? US Airways Group Inc. jumped 17.3 percent and Delta Air Lines Inc. rose 6.2 percent. Both airlines reported profits far better than Wall Street analysts expected. The airlines raised fares during the fourth quarter while keeping costs under control. Delta also cut the number of flights it makes to keep pace with demand.

? WellPoint Inc., the largest U.S. health insurance company based on enrollment, fell 4.8 percent. Its quarterly profit dropped 39 percent, far more than analysts had expected. Its full-year forecast also fell short of forecasts. Medical claims, its largest expense, rose nearly 10 percent in the quarter.

? Guidewire Software Inc. soared 37 percent on its first day of trading. The company, which makes software for the insurance industry, rose to $17.80 after selling initially at $13. The 11-year-old company raised $115 million in its debut ? or about $27 million less than the profit Apple turned in an average day last quarter.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/j3ipt6LDQAQ/Stocks-bounce-on-low-interest-rate-promises

homeland homeland packers giants game golden globe winners 2012 ricky gervais golden globes epidermolysis bullosa miss wisconsin

Game makers react to proposed 'Indie Game' sitcom

Just two of the humorous takes on Twitter.

By Matthew Hawkins

Last week saw the long-awaited debut of "Indie Game: The Movie," which had a world premiere at Sundance. Independent video game makers and their devoted fans believe that the documentary has the potential to shatter preconceived notions about the world of gaming as a whole.

And aside from enriching the overall landscape, there is also the hope that it may also lead to greater visibility and therefore success for everyone featured, plus their work.

So it was these same people who expressed a wide range of emotions Sunday afternoon on Twitter?in reaction to news that?HBO had picked up the rights to the remake.

Sentiment ranged from confusion to sadness, even disgust. Details on the show are fairly sparse, but there's still enough intel to upset, particularly because it sounds like it's going to be a fictional half-hour comedy series.

The fact that power-producer Scott Rudin is already attached gives the project an uncommonly high degree of name value and expectation of quality. This definitely increases the chances of it actually making it on-air.

Indie game maker Joakim Sandberg?sounded off?with: "Soon on HBO: The Indie Bang Theory." Then you have musician?Danny Baranowsky???who worked on "Super Meat Boy," one of the games featured in the movie ??who tweeted: "Indie Game: The Movie - sets acceptance of industry ahead years. Indie Game: The Comedy Series - resets game acceptance to 'lol Donkey Kong.'"

Even less happy about the situation is Phil Fish, creator of "Fez" and a major part of "Indie Game: The Movie." His overall feelings can be best summed up with: "NO SIR, I DON'T LIKE IT." I asked Phil, via Twitter, if he had sold his likeness when agreeing to be part of the project. The answer was no.

The question stemmed from another, very much well-known and successful video game documentary, 2007's "The King of Kong." When New Line Cinema bought the rights to distribute the movie, it also obtained its remake rights and had the two primary stars, Steve Wiebe and Billy Mitchell, sign off on fictionalized likenesses, for an upcoming mockumentary remake.

In the end, there won't be a character named "Phil Fish" in the upcoming sitcom adaptation, though there maybe be the chance that someone closely resembles him ??and anyone else the source material chronicles.?And as the comments above indicate, the primary fear is that a comedic take on the lives on indie game makers risk marginalizing and making a mockery of those actually involved, and may even further reinforce erroneous stereotypes.

But not every game industry pundit is immediately down on the idea of "Indie Game: The Movie: The Sitcom." Take writer Gary Whitta, who is familiar with both the worlds of sides of the fence firsthand; he's a former game journalist and author, whose book is being adapted to a major motion picture starring Will Smith.

Whitta's response to the negative outpour? "LOL at all ppl already deciding an HBO comedy about indie developers must suck. Remember everyone saying a 'Facebook movie' would suck too?"

Related stories:

Be sure to check out In-Game on Facebook, and too keep abreast of Matthew Hawkins, on either Twitter or his personal home-base, FORT90.com.

Source: http://ingame.msnbc.msn.com/_news/2012/01/23/10218918-game-makers-react-to-proposed-indie-game-sitcom

kindle library lending hp ceo hp ceo r e m gurney gurney clemency

Tuesday, January 24, 2012

Verizon releases Q4 results, sees jump in revenue, broadband subscribers, net loss

Verizon has just come out with its Q4 results this morning, ending the fiscal year with yet another solid revenue report, and a decidedly less rosy net loss. According to the provider, total revenue reached $18.3 billion during the final quarter of 2011, up 13 percent from last year. Verizon saw a particularly notable spike in data revenue, which reached $6.3 billion, representing a 19.2 percent increase over the year, and comprising nearly 42 percent of all revenue. Overall, though, VZW finished the quarter with a net loss of $2.02 billion, compared to the $2.64 billion profit it saw last year. The company also saw an increase in its subscriber base, adding 98,000 broadband customers in the span of a quarter, including 201,000 FiOS internet users, 194,000 new FiOS video subscribers, and a net addition of 1.2 million postpaid customers. As far as demographics go, smartphones now comprise a full 44 percent of Verizon's consumer base, up from 39 percent last quarter. For the full year, total revenue finished at $70.2 billion, up 10.6 percent from Big Red's 2010 figures. For more stats and breakdowns, check out the full PR after the break.

Continue reading Verizon releases Q4 results, sees jump in revenue, broadband subscribers, net loss

Verizon releases Q4 results, sees jump in revenue, broadband subscribers, net loss originally appeared on Engadget on Tue, 24 Jan 2012 07:52:00 EDT. Please see our terms for use of feeds.

Permalink Bloomberg  |   | Email this | Comments

Source: http://www.engadget.com/2012/01/24/verizon-releases-q4-results-sees-jump-in-revenue-broadband-sub/

black friday 2011 rhodium uppity uppity stuffing brandon mcinerney brandon mcinerney

Nowitzki will miss 4 games to improve conditioning

Dallas Mavericks forward Dirk Nowitzki (41), of Germany, puts a jump shot over Utah Jazz forward Paul Millsap (24) during the first half of an NBA basketball game in Salt Lake City, Thursday, Jan. 19, 2012. (AP Photo/Steve C. Wilson)

Dallas Mavericks forward Dirk Nowitzki (41), of Germany, puts a jump shot over Utah Jazz forward Paul Millsap (24) during the first half of an NBA basketball game in Salt Lake City, Thursday, Jan. 19, 2012. (AP Photo/Steve C. Wilson)

Dallas Mavericks forward Dirk Nowitzki, of Germany, reacts after hitting a 3-point shot during the first half of the Mavericks' NBA basketball game against the Los Angeles Clippers, Wednesday, Jan. 18, 2012, in Los Angeles. (AP Photo/Mark J. Terrill)

(AP) ? Dirk Nowitzki sat out Dallas' victory in New Orleans on Saturday night and will miss at least three more games so the star forward can get in better game shape while strengthening his sore right knee.

"We just thought it was a good decision for everybody. I'm not happy right now anyways, so the guys are better off when I'm not out there," Nowitzki said. "This gives me time to really do some of the stuff that I couldn't do when my knee was bothering me the last couple weeks. I couldn't lift and run and do the things I needed to do."

Dallas coach Rick Carlisle said he and the Mavericks' training staff decided Nowitzki needed "an uninterrupted eight days of work to resolve some physical issues and conditioning issues," adding that Nowitzki had "no choice" in the matter.

"There was no negotiating," Carlisle said. "The important thing to realize is this is not a rest week. This is a work week and we're going to get some of these minor issues resolved.

"He's going to be busting his (behind) this week. We're going to be on him hard," Carlisle added. "He's got a lot of work to do and if things go like we think they'll go, by the end of the week he'll be back and ready to play."

Nowitzki has been playing with a protective sleeve on his right knee and at times has complained of stiffness and irritation. His 17.5 points per game this season is a little more than four points below his career average.

He said his knee has been feeling better recently, but added that by "continuously playing on it, it wasn't getting better quick enough."

Nowitzki played as recently as Wednesday night's 94-91 victory at Utah, but was held to what is for him a relatively low 12 points to go with five rebounds.

"I couldn't go by anybody off the dribble and that's part of my game. Right now I'm basically a pop-up shooter every time I caught it, and if I didn't have (the shot), I had to swing it because I just couldn't make a move, couldn't go by anybody," Nowitzki said. "I didn't feel comfortable. So that's something that I've got to work on this week is putting the ball on the floor and get comfortable and really getting confidence in my leg strength ... and I'll be back to my old self."

Lamar Odom started for Nowitzki and scored 16 points in an 83-81 win over the Hornets.

"I liked the way Lamar played. We're a running team, so with him starting and getting more minutes, this is an opportunity for him to get in the habit of running and to raise his level of conditioning," Carlisle said. "This week is a big week for him."

Reserve forward Brian Cardinal expressed confidence in the Mavericks' ability to compensate for Nowitzki's absence.

"The beauty of our team is our depth," Cardinal said. "It's just not one person that's going to have to replace him. We're going to have to collectively."

Cardinal said the compressed game schedule caused by the recent NBA lockout was making it tougher for Nowitzki to work his way back into shape.

"Without having a lot of practice time it's hard. All we do is play games," Cardinal said. "So it's hard to work on your game, work on your craft. This gives him that opportunity and at the same time it gives other people an opportunity (to play), so I think it's a win-win for us."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-01-22-Mavericks-Nowitzki/id-f451174ee99e45268c20411ae9dddcca

turkey recipes turkey recipes happy holidays norad how to carve a turkey how to cook a turkey yorkshire pudding

Monday, January 23, 2012

BlackBerry maker co-CEOs step down as co-CEOs (AP)

TORONTO ? BlackBerry maker Research in Motion's co-CEOs, Jim Balsillie and Mike Lazaridis, announced they have stepped down as co-CEOs and co-chairmen of the once-iconic company that has struggled to compete in recent years.

The RIM founders have been replaced by Thorsten Heins, a chief operating officer who joined RIM four years ago from Siemens AG, RIM said Sunday.

The Canadian company turned the email smartphone into a ubiquitous device that many could not live without, but U.S. users have moved on to flashier touch-screen phones such as Apple's iPhone and various competing models that run Google's Android software. RIM has suffered a series of setbacks and has lost tens of billions in market value.

RIM said last month that new phones deemed critical to the company's future would be delayed until late this year. And its PlayBook tablet, RIM's answer to the Apple iPad, failed to gain consumer support, forcing the company to deeply discount it to move the devices off store shelves.

Many shareholders and analysts have said a change or sale of the company has been needed, but the sudden departure of the two founders from their top jobs wasn't expected despite their promises that they would examine the co-CEO and co-chairmen structure.

Balsillie and Lazaridis have long been celebrated as Canadian heroes, even appearing in the country's citizenship guide for new immigrants as models of success. They headed Waterloo, Ontario-based RIM together for the past two decades.

"There comes a time in the growth of every successful company when the founders recognize the need to pass the baton to new leadership. Jim and I went to the board and told them that we thought that time was now," Lazaridis said in a statement.

Lazaridis will take on a new role as vice chairman of RIM's board and chairman of the board's new innovation committee. Balsillie remains a member of the board.

The two remain two of RIM's biggest shareholders.

"I agree this is the right time to pass the baton to new leadership, and I have complete confidence in Thorsten, the management team and the company," Balsillie said in the statement. "I remain a significant shareholder and a director and, of course, they will have my full support."

Analysts have said RIM's future depends on its much-delayed new software platform as RIM has tried and failed to reinvigorate the BlackBerry. Apple co-founder Steve Jobs said in late 2010 that RIM would have a hard time catching up to Apple because RIM has been forced to move beyond its area of strength and into unfamiliar territory of trying to become a software platform company.

Heins, 54, said Lazaridis and Balsillie took RIM in the right direction and said he's committed to the new software.

"We are more confident than ever that was the right path. It is Mike and Jim's continued unwillingness to sacrifice long-term value for short-term gain which has made RIM the great company that it is today. I share that philosophy and am very excited about the company's future," Heins said.

Barbara Stymiest, a former chief operating officer of the Royal Bank of Canada who has been a member of RIM's board since 2007, has named chair of the board of directors. RIM also announced that Prem Watsa, the chief executive of Fairfax Financial Holdings, is a new board member. Watsa has become a significant shareholder.

Lazaridis said he was so confident in the future direction of the company that he intends to purchase an additional $50 million of the company's shares on the open market.

RIM was worth more than $70 billion a few years ago but now has a market value of $8.9 billion.

The company still has 75 million active subscribers, but many analysts believe RIM will lose market share internationally as it has in the U.S. Market researcher NPD Group said RIM's market share of smartphones in the U.S. declined from 44 percent in 2009 to 10 percent in 2011.

Balsillie acknowledged in December that the last few quarters have been among the most challenging times in the company's history.

Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/ap/20120123/ap_on_bi_ge/cn_rim_ceos_resign

new facebook layout new facebook layout yalta oman oman unforgettable metta world peace

Bryce Dallas Howard Welcomes Daughter Beatrice Jean

Bryce Dallas Howard and husband Seth Gabel welcomed a daughter on Thursday, Jan. 19, Bryce's proud father, movie director Ron Howard, Tweeted on Sunday.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/pca7Cbn3gm8/

nhl realignment kristin chenoweth country music awards new earth light year light year michelle rounds

Sunday, January 22, 2012

Investigators achieve important step toward treating Huntington's disease

ScienceDaily (Jan. 19, 2012) ? A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death.

The findings, now available online in the journal Molecular and Cellular Neuroscience, suggest a promising approach that might block the disease from advancing.

"For the first time, we have been able to successfully deliver inhibitory RNA sequences from stem cells directly into neurons, significantly decreasing the synthesis of the abnormal huntingtin protein," said Jan A. Nolta, principal investigator of the study and director of the UC Davis stem cell program and the UC Davis Institute for Regenerative Cures. "Our team has made a breakthrough that gives families affected by this disease hope that genetic therapy may one day become a reality."

Huntington's disease can be managed with medications, but currently there are no treatments for the physical, mental and behavioral decline of its victims. Nolta and other experts think the best chance to halt the disease's progression will be to reduce or eliminate the mutant huntingtin (htt) protein found in the neurons of those with the disease. RNA interference (RNAi) technology has been shown to be highly effective at reducing htt protein levels and reversing disease symptoms in mouse models.

"Our challenge with RNA interference technology is to figure out how to deliver it into the human brain in a sustained, safe and effective manner," said Nolta, whose lab recently received funding from the California Institute for Regenerative Medicine to develop an RNAi delivery system for Huntington's disease. "We're exploring how to use human stem cells to create RNAi production factories within the brain."

Huntington's disease affects more than a quarter of a million Americans. The disorder can be passed down through families even if only one parent has the abnormal huntingtin gene. The disease is caused by a mutation in the gene, which is composed of an abnormally repeating building block of DNA that appears on the fourth chromosome. While the building block pattern normally repeats up to 28 times on the chromosome, too many repeats cause an abnormal form of protein -- known as the huntingtin protein -- to be made. The huntingtin protein accumulates in the brain, causing the disease's devastating progression. Individuals usually develop symptoms in middle age if there are more than 35 repeats. A more rare form of the disease occurs in youth when the abnormal DNA pattern repeats many more times.

The UC Davis research team showed for the first time that inhibitory RNA sequences can be transferred directly from donor cells into target cells to greatly reduce unwanted protein synthesis from the mutant gene. To transfer the inhibitory RNA sequences into their targets, Nolta's team genetically engineered mesenchymal stem cells (MSCs), which were derived from the bone marrow of unaffected human donors. Over the past two decades, Nolta and her colleagues have shown MSCs to be safe and effective vehicles to deliver enzymes and proteins to other cells. She said finding that MSCs can also transfer RNA molecules directly from cell to cell, in amounts sufficient to reduce levels of a mutant protein by over 50 percent in the target cells, is a discovery that has never been reported before and offers great promise for a variety of disorders.

"Not only is finding new treatments for Huntington's disease a worthwhile pursuit on its own, but the lessons we are learning are applicable to developing new therapies for other genetic disorders that involve excessive protein development and the need to reduce it," said Nolta, who recently received a Transformative Research Grant from the National Institutes of Health to study how mesenchymal stem cells can transfer microRNA and other factors into the cells of damaged tissues, and how that process can be harnessed to treat injuries and disease. "We have high hopes that these techniques may also be utilized in the fight against some forms of amyotrophic lateral sclerosis (Lou Gehrig's disease) as well as Parkinson's and other conditions."

The article, "Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin," was co-authored by Scott D. Olson, now with Texas Medical Center in Houston. Other authors were Amal Kambal, now at Washington University in St. Louis; and Kari Pollock, Gaela-Marie Mitchell, Heather Stewart, Stefanos Kalomoiris, Whitney Cary, Catherine Nacey and Karen Pepper, with the UC Davis Institute for Regenerative Cures. Funding for the research was provided by the California Institute for Regenerative Medicine and Team KJ.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of California - Davis Health System.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Scott D. Olson, Amal Kambal, Kari Pollock, Gaela-Marie Mitchell, Heather Stewart, Stefanos Kalomoiris, Whitney Cary, Catherine Nacey, Karen Pepper, Jan A. Nolta. Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin. Molecular and Cellular Neuroscience, 2011; DOI: 10.1016/j.mcn.2011.12.001

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/ECKADP85pRg/120119163253.htm

prime rib recipe norad santa tracker vince carter sweet potato casserole safeway standing rib roast powerball

Saturday, January 21, 2012

Who is Obama?s favorite Middle East leader? (Powerlineblog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/189246221?client_source=feed&format=rss

iphone 5 case pawpaw pawpaw cantaloupe cantaloupe credit union greys anatomy

Union spends big on ad attacking Romney in Florida

Republican presidential candidate, former Massachusetts Gov. Mitt Romney campaigns at Charleston Area Convention Center in North Charleston, S.C., Friday, Jan. 20, 2012. (AP Photo/Charles Dharapak)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney campaigns at Charleston Area Convention Center in North Charleston, S.C., Friday, Jan. 20, 2012. (AP Photo/Charles Dharapak)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, accompanied by South Carolina Gov. Nikki Haley, throws an apple out to the audience as he campaign at Harmon Tree Farm in Gilbert, S.C., Friday, Jan. 20, 2012. (AP Photo/Charles Dharapak)

(AP) ? In what is organized labor's first major investment in the Republican presidential primary, the American Federation of State, County and Municipal Employees is spending almost $1 million in Florida on a television ad attacking Mitt Romney's business career.

Romney and his allies have had the Florida airwaves to themselves for nearly a month as the rest of the political world focuses on South Carolina's Saturday primary.

The new ad links Romney's business career to that of Florida Gov. Rick Scott. "Corporate greed. Medicare fraud. Sound familiar?" the narrator asks as Romney appears on the screen next to Scott, also a Republican former businessman.

Facing similar attacks from his Republican rivals, Romney has been increasingly forced to defend his years at Bain Capital, a private equity company where the former Massachusetts governor accumulated his personal fortune.

"A number of the other candidates are already pummeling Romney in South Carolina," said AFSCME political director Larry Scanlon. "We just think it's very timely. The Florida voters are going to be tuning in."

Scanlon suggested that Florida represents the last best chance to stop Romney's march toward his party's presidential nomination. He's leading in Florida polls, although Saturday's contest in South Carolina could shift the dynamic if Romney stumbles.

AFSCME will be very active in the general election, Scanlon says, but he adds that the union will take a "wait and see" approach on whether to invest any more resources in the GOP primary.

"We have 25,000 members in Florida. We have 1.6 million members around the country who have a great stake in the election of the next president," he said. "We've always been big dogs in politics."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-01-20-Florida-Romney-Ad/id-4f863401f7ae4cd9ab253fcc065182ca

new ipod touch new ipod touch dwts results vanessa paradis vanessa paradis when will ios 5 be released when will ios 5 be released